Dr. David Sinclair Supplements and Anti-Aging Diet – from Fasting to Extending Human Lifespan

Dr. David Andrew Sinclair’s aging and longevity work is vastly influential. His diet proposes to expand the human lifespan and his book ‘Lifespan’ may just change your life for the better.

This article includes a video of Dr. David Sinclair’s diet, as well as the supplements he’s using this year.

David Sinclair
Dr David Sinclair, PHD. Source Wikimedia (Creative Commons)

Who is David Sinclair?

Dr. David Andrew Sinclair AO (born June 26, 1969) is an Australian biologist and academic known for his research on aging and epigenetics. He is a Professor of Genetics at Harvard Medical School and the Co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard Medical School.

Dr. Sinclair gained notoriety with his book, Lifespan, which proposed a radical new theory of aging suggesting that the aging hallmarks are symptoms of epigenetic changes. In addition, he has held interviews with podcasts such as Lifespan with Dr. David Sinclair to discuss his aging research and top tips for longevity and what it’s like to work in his lab.

Dr. Sinclair’s name comes to mind when talking about aging, healthy lifespan, and longevity genes, as he is an outstanding researcher in the field and has developed innovative ideas related to advancing healthy lifespan. His research group is a world leader in the understanding of why we age and how to extend healthy lifespan through genetic interventions, diet, and supplements.

As Dr. Sinclair explains, aging is a disease that is treatable and he believes everyone can live past 100 years old if they take action now by following the advice from his book Lifespan and using his diet plan, supplements, and other recommendations for health.

Dr. David Sinclair Harvard Career and Other Endevours

Dr. David Sinclair is a world-renowned scientist and professor of genetics at Harvard Medical School. He is the co-director of the Paul F. Glenn Center for Biology of Aging Research and has a rich background in genetics and epigenetics. His research focuses on understanding the role of sirtuins, which control aging and age-related diseases.

In 1999, Dr. Sinclair was recruited to Harvard Medical School where his laboratory’s research has focused primarily on understanding the role of sirtuins in controlling aging and age-related diseases. From there, his career took off like a rocket, and he soon left MIT to run his own lab at Harvard Medical School and become an assistant professor.

Throughout his career, Sinclair has co-founded several biotechnology companies, including Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio and Liberty Biosecurity. He has also published numerous scientific articles in journals such as Nature, Science and Cell Metabolism, which have been widely recognized by the scientific community.

Dr. Sinclair recently released a new book entitled Lifespan: Why We Age—and Why We Don’t Have To, which explores the latest science behind why we age and how to live longer and healthier lives. He also hosts a podcast series called “Lifespan” where he discusses his research with experts in the field of aging research.

Research on Aging and Epigenetics

Dr. David Sinclair is a leading researcher in the field of aging and epigenetics. His groundbreaking research studies how changes to DNA organization and regulation can accelerate or reverse signs of aging in mice. In 2008, Sinclair, a geneticist at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, published a paper in Cell arguing that epigenetic dysregulation in the form of information loss contributes to an increase in entropy and thus aging in all living things.

His latest research has focused on understanding how epigenetic reprogramming can be used to reset cells and potentially extend lifespan. Sinclair’s team has investigated how reprogramming cells can reset their epigenetic clocks, which could lead to improved health and longevity. These studies support the hypothesis that mammalian cells maintain a kind of backup copy of epigenetic software that, when restored, can restore some youthful characteristics to cells and tissues.

In 2019, Sinclair released his book Lifespan: Why We Age—and Why We Don’t Have To, which offers insights into the current understanding of aging and provides strategies for slowing the process down. He also regularly speaks about his findings on the podcast Lifespan with Dr. David Sinclair, where he discusses topics related to aging breakthroughs and lifestyle changes to improve longevity.

In addition to his research and writing, Dr. David Sinclair is an advocate for healthy aging through diet and supplements. He recommends a diet rich in antioxidants like blueberries and salmon as well as supplements like resveratrol, NAD precursors, vitamins C and D, omega-3 fatty acids, probiotics, glutathione, magnesium citrate, and more.

How Old is Dr. David Sinclair?

Dr. David Sinclair’s age is 53 but he looks much younger, no doubt through his diet and supplementation. At this age, he continues to inspire those around him with his passion for understanding aging and unlocking its secrets through scientific exploration and innovation.

Sinclair added 10 years to his life using InsideTracker. Despite being 53 years old, he claims to have the blood profile of someone who is 33 biologically.

Recently, Sinclair sat down with InsideTracker to discuss his age-defying lifestyle and the success of his anti-aging strategies. During the interview, Sinclair revealed that he feels in his 30s despite being 53 years old, and that he was able to shave a decade off his life using a health-tracking device.

By following a healthy diet, taking specific supplements, and staying active, Sinclair is a perfect example of how one can stay young for longer.

Sinclair’s Innovations in the Field of aging and epigenetics

Dr. David Sinclair has been at the forefront of groundbreaking research in the field of aging and epigenetics. His work has been instrumental in advancing the current understanding of how aging works and how it can be managed to extend life expectancy.

Recently, Dr. Sinclair has made major strides in the field of healthy aging through his research on Sirtuins, a group of proteins that regulate gene expression. His work on Sirtuins has led to the development of drugs and treatments that can help slow down the aging process. Additionally, Dr. Sinclair has conducted extensive research into cellular senescence, a process in which cells become permanently inactive as they age, leading to tissue damage and disease.

In his recent book Lifespan, Dr. Sinclair explains his findings on how lifestyle changes such as diet, exercise, sleep, and supplements can help extend one’s life expectancy. He also discusses how the use of certain drugs such as Metformin can increase lifespan by up to 30%. This is a major breakthrough in the field and could lead to treatments that could significantly reduce age-related diseases and disability.

Furthermore, Dr. Sinclair is part of an international team of scientists who have recently established The Academy of Healthy Aging. This academy is dedicated to researching new innovations in the field with the aim of developing new treatments for age-related diseases and improving overall healthspan.

Dr. Sinclair’s research is revolutionizing our understanding of aging and he is helping pave the way for future generations to live longer and healthier lives.

Dr. Sinclair’s Diet

Dr. Sinclair has developed a diet to aid in achieving optimal health and longevity. He follows a combination of three main principles: nutritious foods, intermittent fasting, and a healthy plant-based diet. For his meals, he focuses on eating vegetables, mushrooms, pulses, whole grains, white meat, and fish. He also practices intermittent fasting by skipping breakfast and lunch on most days and having a much smaller evening meal than average.

David Sinclair uses intermittent fasting daily, eating just two meals a day.

Generally, a typical day looks like this:

  • eating a plant-based diet.
  • skip breakfast.
  • consume olive oil or yogurt with supplements.
  • drinking a lot of water.
  • eating very low sugar and starchy foods.

The video below is from his book: Lifespan, and talks about what and when to eat.

Dr. Sinclair believes that reducing inflammation is one of the key components to living a longer life, as it is linked to age-related diseases. He recommends avoiding sugar as it can increase inflammation in the body. He also recommends reducing one’s meat intake as it is associated with higher levels of chronic inflammation.

The takeaways from this podcast are to eat less, avoid sugar, reduce meat intake, and eat more nutrient-dense plant-based foods such as vegetables and whole grains. Dr. Sinclair has himself adopted a vegetarian lifestyle in order to follow this dietary advice more closely.

★ For more information on his diet, I recommend reading his book Lifespan.

Dr. David Sinclair’s Supplements in 2023

Please use this information at your own discretion and for education purposes only.

Dr. David Sinclair has been researching and developing supplements to help slow down the aging process for many years. He recommends a daily regimen of one gram of Nicotinamide Mononucleotide (NMN) and 0.5 grams of Resveratrol every morning, which he believes can help to slow down the aging process and improve overall health. His research suggests that these supplements can help to reduce inflammation, promote healthy cell growth, and protect against oxidative damage.

In addition to these two supplements, Dr. Sinclair also recommends Fisetin and Spermadine for their anti-aging effects. Fisetin is a polyphenol found naturally in certain plants and fruits, while Spermadine is an amino acid found in some seeds and nuts. Dr. Sinclair believes that these supplements can help to improve cognitive function, reduce inflammation, and boost the immune system.

Dr. Sinclair has also developed a diet plan that he believes is beneficial for anti-aging purposes as well as overall health and wellness. He suggests eating foods rich in antioxidants such as fruits and vegetables, avoiding processed foods as much as possible, and limiting alcohol consumption. He also recommends eating plenty of protein to maintain muscle mass and regular exercise to keep the body healthy and active.

Dr. David Sinclair’s new book Lifespan outlines his research on aging and epigenetics as well as his dietary advice and supplement recommendations. The book is available for purchase online or in bookstores across the US. For those looking to purchase Dr. Sinclair’s recommended supplements, they are available online from a variety of retailers or in some health food stores across the US.

★ For a full list of supplements, I recommend reading his book Lifespan.

Interview with Dr. Sinclair

In one episode of the podcast Lifespan with Dr. David Sinclair, the renowned scientist and professor of genetics at Harvard Medical School talks about his groundbreaking research on aging and epigenetics.

During the interview, Dr. Sinclair discussed how he has identified multiple pathways to manipulate aging and how his research has been used to develop treatments that can extend lifespan and improve health in older adults. He also talked about his new book, Lifespan, which provides advice on how to slow down aging and live a healthy life.

Additionally, Dr. Sinclair discussed his own diet and supplements regimen to achieve longevity and how he believes that 80% of our health in old age is up to us. He also shared his plans to live past 100 years old and encourages others to do the same.

Finally, Dr. Sinclair concluded with a discussion on the importance of self-care and how we can all make changes in our lifestyle to extend our lifespan.

The interview with Dr. Sinclair provided a fascinating insight into his research on aging and epigenetics, as well as his own personal journey towards achieving longevity. It is clear from this episode that there is much we can do to extend our lifespan and improve our health in old age.

The video below is from David’s podcast, Lifespan.

David Sinclair’s Website and Other Bio Pages

You can find Dr. David Sinclair’s website here and his Wikipedia page here.

The Knowledge Project Podcast Interview

What is Dr. David Sinclar’s diet and what does it include?

Professor David Sinclair’s “longevity diet” includes low-calorie meals, focusing on plant-based foods with high levels of antioxidants, as well as occasional fasting and exercise. He also suggests taking various supplements to help maintain good health.

What vitamins does David Sinclair take?

David Sinclair recommends taking nicotinamide riboside (NR) and resveratrol. He also takes pterostilbene, metformin, DHEA, omega-3 fatty acids, zinc, magnesium, and vitamin D.

What does Sinclair take daily?

Sinclair takes a multivitamin each morning and consumes a nutritious breakfast. He also drinks lots of water during the day to keep hydrated. Each evening, he has some probiotics and eats a small snack before going to sleep.

What did David Sinclair discover?

David Sinclair is the biologist who discovered the molecule nicotinamide adenine dinucleotide (NAD ), which plays an essential role in preserving cell health and life. His discovery changed how scientists consider aging since NAD is necessary for processes linked to longevity.

What brand of NMN does David Sinclair use?

Professor David Sinclair uses Tru Niagen brand NMN. It is a patented, branded form of NMN made with strict quality control standards and is considered to be among the highest quality available for helping to slow the aging process.

★ Please note: the FDA banned NMN (see question further down). Do your own due dilligence and please check with your doctor before consuming this supplement.

How do you get an NMN naturally?

NMN can be obtained through supplements that are made with lab-tested ingredients from reputable manufacturers. Make sure you read the label and follow the directions precisely prior to taking any NMN supplement, as it is not naturally found in large amounts in food sources.

Is NMN just vitamin B3?

NMN stands for Nicotinamide Mononucleotide, which is a precursor to Vitamin B3 (also known as Niacin or Nicotinic Acid). It helps the body convert food into energy and has been found to have positive effects on aging and overall health.

Does NMN make you look younger?

There is only minimal study suggesting that NMN might help decrease indications of aging, such as wrinkles and age spots. Further exploration must be undertaken to identify the long-term efficiency of NMN in improving skin health and appearance.

Is it worth it to take NMN?

Taking NMN may be beneficial for those who want to enhance their general wellbeing and quality of life. Nicotinamide Mononucleotide (NMN) is a significant intermediary in the formation of energy molecules and has been noted to have many advantages such as expanding life expectancy and enhancing healthy aging.

What foods have the most NMN?

NMN is a form of Vitamin B3 which can be found in milk, mushrooms, broccoli, edamame and tomatoes. It has been examined to potentially increase energy levels and has been associated with several health benefits.

Does broccoli have NMN?

Yes, broccoli contains NMN. It is a vital nutrient that can be found in many fruits and vegetables, as well as animal-derived foods such as dairy products, meat and fish. Other plants with NMN are cabbage, kale and spinach.

At what age should you start taking NMN?

It is suggested that people over the age of 35 should start taking NMN supplements, as this is when some of the signs of aging usually begin to appear. Although safe and effective for all ages, those aged over 35 may gain the most benefits from its use as a supplement.

What are the side effects of taking NMN?

The most commonly reported side effects associated with taking NMN are mild digestive issues such as nausea, diarrhea and stomach cramps. Other less common side effects may include headaches, dizziness and fatigue. If you experience any negative symptoms while taking NMN, discontinue use and consult your doctor immediately.

Is sleep a side effect of NMN?

No, sleep is not a known side effect of NMN. Some people may feel fatigued or drowsy when taking NMN since their body uses energy to metabolize the supplement. Always consult with your doctor before using any medications or supplements.

Why did the FDA ban NMN?

The U.S. Food and Drug Administration (FDA) recently issued a warning about NMN, a dietary supplement that was being sold for anti-aging and other health benefits. The FDA banned the supplement because it had not been tested to determine its safety and effectiveness, as well as containing potentially dangerous ingredients that were not present on the label.

Which is better NMN or resveratrol?

NMN is more effective than resveratrol. It has been demonstrated to increase the body’s energy production, whereas no such effect has been demonstrated with resveratrol. Furthermore, NMN may also be better absorbed by the body than resveratrol.

What does David Sinclair eat for breakfast?

David Sinclair typically has a nutritious breakfast that consists of eggs and oatmeal. He will often add fresh fruit like strawberries or blueberries to get an additional nutritional boost. Additionally, he will sometimes include nuts for crunchiness or avocado for creaminess.

How long does David Sinclair fast?

David Sinclair fasts for 20 hours every day and eats all of his meals within a 4-hour window. He begins his day with coffee and some vitamins before having lunch around 1 pm. After that, he avoids dinner and snacks until the following day’s lunch.

Can skipping breakfast reverse aging?

Skipping breakfast is not a guaranteed fix for aging, however research has suggested that it could be useful. According to a study from Yale University, fasting could lessen inflammation which is linked to several age-related ailments. Not eating breakfast might likewise help manage blood sugar levels and decrease the chance of diabetes or other age-related illnesses.

Is David Sinclair vegetarian?

David Sinclair is not vegetarian, but he is a big advocate for consuming more plants and less meat. He believes that science-based nutrition is important to understand the effects of different foods on our health. David also recommends eating organic foods when possible.

Is David Sinclair Against Vegetarianism?

Yes, David Sinclair does not follow a vegetarian diet and often speaks out against it. He believes that the best way for people to optimize their health and longevity is through a balanced diet of lean proteins, fruits, and vegetables.

Does David Sinclair take statins?

No, David Sinclair does not take statins to lower his cholesterol. He thinks that the medicines do more damage than good, and he is attempting to discover novel methods for preventing cardiovascular disease without utilizing medication.

Why does David Sinclair take metformin?

David Sinclair believes that metformin, an anti-aging drug he takes twice daily, can activate specific genes in the body to slow down aging. He additionally maintains that metformin can help reduce the risk of cancer and other age-related diseases.

Is spermidine anti-aging?

Spermidine has been demonstrated to possess anti-aging characteristics. It can help reduce inflammation, shield cells from harm, and boost cell longevity. Furthermore, it might help decrease the danger of age-related ailments including cancer and cardiovascular disease.

Dr. David Sinclair Resources

Dr. David Sinclair has a wealth of resources available to those looking to learn more about his research and innovations in the field of aging and epigenetics. He has published a book, Lifespan, which provides an in-depth look into the progress he has made in this area. Additionally, he is a frequent guest on various podcasts, including Revolution Health Radio, where he discusses his research and strategies for improving the aging process. Dr. Sinclair is also affiliated with the Academy for Health and Lifespan Research and is often interviewed for various publications. Finally, he has his own website, where visitors can learn more about his work and find additional resources.